An invasive meningococcal infection is a serious illness that can become life-threatening within a few hours after initial general symptoms such as headache and fever. The bacteria Neisseria meningitidis, also known as meningococcus, usually cause purulent meningitis or sepsis (commonly also referred to as blood poisoning). Meningococcal disease is very rare in Germany. There are less than 4 cases per 1 million people per year.
Meningococcus primarily colonises the human nasopharynx. The pathogens can be transmitted to others through close contact, such as through saliva or nasal secretions. Since meningococci die quickly outside the body, an encounter between people without close contact does not usually result in transmission.
An illness will commonly involve the sudden onset of general symptoms such as headache, fever, shivering and dizziness with severe malaise. A life-threatening condition can develop within a few hours.
Meningococci cause two main clinical presentations, which can occur individually or together:
Complications and long-term sequelae occur in 10 to 20% of those affected. Meningococcal meningitis can lead to cranial nerve palsies, seizures, intellectual impairment or learning difficulties as well as deafness. Sepsis can lead to tissue damage and even to the death of individual limbs.
The mortality rate for meningococcal meningitis is 1%, for sepsis around 13% and for the severe form of septic shock around 33%.
In infants and young children, the symptoms of meningococcal disease are often less typical. Symptoms may include fever, vomiting, cramps, irritability or drowsiness, crying and a bulging or hard fontanelle (gap between the cranial bones). By contrast, neck stiffness may be absent.
The first symptoms appear 2 to 10 days after infection, usually after 3 to 4 days. Those affected are contagious for up to 7 days before the onset of symptoms. The disease is usually treated with antibiotics. 24 hours after the start of effective antibiotic therapy, patients are no longer contagious.
Meningococcal disease can occur at any age. Infants and toddlers in the first and second years of life are most frequently affected, though adolescents between the ages of 15 and 19 are also more likely to fall ill with it. Close contacts of infected persons, especially people in the same household, are at an increased risk of becoming infected.
There are different types of meningococcus (serogroups), which are distributed differently around the world. In Germany, the majority of illnesses in children are caused by meningococcal serogroup B, and the majority in adults are caused by serogroup Y. Serogroups C and W are rarer. Various vaccines are available that protect against different types of meningococcus.
The Standing Committee on Vaccination (STIKO) recommends:
The local health authority (Gesundheitsamt) can provide you with further advice. Since meningococcal infections must be reported, it has information on the current situation and experience in dealing with the disease.
More (specialist) information is also available online from the Robert Koch Institute (www.rki.de/meningokokken).
Please also note the information for travellers (www.auswaertiges-amt.de).
Information on infection control through vaccination can be found on the Federal Institute of Public Health website (www.infektionsschutz.de).